Anugerah Akademi

• 2006: Tercalon untuk Academy Award for Best Actress--Transamerica

Anugerah Golden Globe

• 2000: Tercalon untuk Best Actress in a TV Series - Comedy/Musical -- Sports Night
• 2005: Tercalon untuk Best Actress in a TV Series - Comedy/Musical -- Desperate Housewives
• 2006: Tercalon untuk Best Actress in a TV Series - Comedy/Musical -- Desperate Housewives
• 2006: Memenangi Best Actress in a Motion Picture - Drama -- Transamerica
• 2007: Tercalon untuk Best Actress in a TV Series - Comedy/Musical -- Desperate Housewives

Anugerah Emmy

• 2005: Memenangi Primetime Emmy Award for Outstanding Lead Actress - Comedy Series -- Desperate Housewives

Anugerah Independent Spirit

• 2006: Memenangi Best Female Lead -- Transamerica

National Board of Review

• 2005: Memenangi for Best Actress -- Transamerica

OBIE Award

• 1994-95: memenangi for her performance as Donny in David Mamet's "Cryptogram"

Screen Actors Guild Awards

• 2000: Tercalon untuk Outstanding Performance by an Ensemble in a Comedy Series -- Sports Night
• 2005: Memenangi Outstanding Performance by an Ensemble in a Comedy Series -- Desperate Housewives
• 2006: Tercalon untuk Outstanding Performance by a Female Actor in a Leading Role -- Transamerica
• 2006: Memenangi Outstanding Performance by an Ensemble in a Comedy Series -- Desperate Housewives
• 2006: Memenangi for Outstanding Performance by a Female Actor in a Comedy Series -- Desperate Housewives
• 2007: Tercalon untuk Outstanding Performance by an Ensemble in a Comedy Series -- Desperate Housewives
• 2007: Tercalon untuk Outstanding Performance by a Female Actor in a Comedy Series -- Desperate Housewives